(+)-(3r,5s),Tert-butyl 7-[4-(4-fluorophenyl)-6-lsopropyl-2-(N-methyl-N-methylsulphonylamino)-primidin-5- YI-3,5-dihydroxy-6(E)-heptenate(R1.5 Or T-butyl-rosuvastatin)(R2)

  • CAS：355806-00-7
  • purity：99%
Inquiry

Details

Bulk supply high purity (+)-(3r,5s),Tert-butyl 7-[4-(4-fluorophenyl)-6-lsopropyl-2-(N-methyl-N-methylsulphonylamino)-primidin-5- YI-3,5-dihydroxy-6(E)-heptenate(R1.5 Or T-butyl-rosuvastatin)(R2) 355806-00-7, Paid sample available

  • Molecular Formula: C26H36FN3O6S
  • Molecular Weight: 537.653
  • Appearance/Colour: white to off-white crystal powder 
  • Vapor Pressure: 0mmHg at 25°C 
  • Refractive Index: 1.564 
  • Boiling Point: 704.158 °C at 760 mmHg 
  • PKA: 13.38±0.20(Predicted) 
  • Flash Point: 379.661 °C 
  • PSA： 138.30000 
  • Density: 1.26 g/cm3 
  • LogP: 4.73960 

tert-Butyl rosuvastatin(Cas 355806-00-7) Usage

InChI:InChI=1/C26H36FN3O6S/c1-16(2)23-21(13-12-19(31)14-20(32)15-22(33)36-26(3,4)5)24(17-8-10-18(27)11-9-17)29-25(28-23)30(6)37(7,34)35/h8-13,16,19-20,31-32H,14-15H2,1-7H3/b13-12+/t19-,20-/m1/s1

355806-00-7 Relevant articles

PROCESS FOR MANUFACTURE OF ROSUVASTATIN CALCIUM AMORPHOUS

-

Page/Page column 7; 8, (2019/01/22)

Disclosed here is a process for the prep...

Purification method of rosuvastatin calcium key intermediate

-

Paragraph 0053-0055, (2019/05/08)

The invention provides a purification me...

INTERMEDIATE COMPOUND FOR PREPARING ROSUVASTATIN CALCIUM AND METHOD FOR PREPARING ROSUVASTATIN CALCIUM THEREFROM

-

, (2017/02/24)

Provided are an intermediate compound fo...

Synthesis method of chiral isomer impurities of rosuvastatin calcium

-

Paragraph 0034-0036; 0042, (2017/12/27)

The invention relates to a synthesis met...

355806-00-7 Process route

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
Conditions Yield
(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester; With triethyl borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.25h; Inert atmosphere;
With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h; Inert atmosphere;
90.6%
(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h;
With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3h;
86%
With sodium hydroxide; water; In ethanol; at 20 ℃; for 2h;
With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - -75 ℃; for 1.5h;
10.5 g
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate
1235588-97-2

tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
Conditions Yield
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate; With water; acetic acid; at 40 - 60 ℃; for 3h;
With sodium hydrogencarbonate; In water; ethyl acetate;
95%
With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;
95%

355806-00-7 Upstream products

  • 289042-12-2
    289042-12-2

    2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

  • 910867-13-9
    910867-13-9

    (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester

  • 1007871-85-3
    1007871-85-3

    tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

  • 1235588-97-2
    1235588-97-2

    tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate

355806-00-7 Downstream products

  • 287714-41-4
    287714-41-4

    rosuvastatin

  • 917805-72-2
    917805-72-2

    C4 H11 N*C22 H28 FN3 O6 S

  • 917805-79-9
    917805-79-9

    rosuvastatin tetramethyl ammonium salt

  • 862994-56-7
    862994-56-7

    E-7-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

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