6-(2-Chloro-5-fluoropyriMidin-4-y1)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]iMidazole

  • CAS：1231930-42-9
  • purity：99%
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Details

Good factory exports good 6-(2-Chloro-5-fluoropyriMidin-4-y1)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]iMidazole 1231930-42-9

  • Molecular Formula: C15H13ClF2N4
  • Molecular Weight: 322.745
  • Boiling Point: 509.6±45.0 °C(Predicted) 
  • PKA: 2.32±0.10(Predicted) 
  • PSA： 43.60000 
  • Density: 1.42±0.1 g/cm3(Predicted) 
  • LogP: 4.31420 

1231930-42-9 Relevant articles

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1231930-42-9 Process route

6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8

6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-42-9

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Conditions
Conditions Yield
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;
2,4-dichloro-5-fluoropyrimidine; With iron(III)-acetylacetonate; In tetrahydrofuran; at 55 - 60 ℃; Inert atmosphere;
76%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In diethylene glycol dimethyl ether; at 80 ℃; for 4h; Inert atmosphere;
60%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-42-9

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Conditions
Conditions Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 5h; Inert atmosphere;
78.5%

1231930-42-9 Upstream products

  • 1231930-37-2
    1231930-37-2

    4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole

  • 2927-71-1
    2927-71-1

    2,4-dichloro-5-fluoropyrimidine

  • 1118-69-0
    1118-69-0

    N-isopropylacetamide

  • 1231930-29-2
    1231930-29-2

    N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine

1231930-42-9 Downstream products

  • 1231929-97-7
    1231929-97-7

    N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

  • 1231930-82-7
    1231930-82-7

    LY2835219

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