5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine (Z7 Bromine)

  • CAS：799842-07-2
  • purity：99%
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Factory Supply Industrial Grade 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine (Z7 Bromine) 799842-07-2 with Best Price

  • Molecular Formula: C16H19BrFN3O2S
  • Molecular Weight: 416.314
  • Vapor Pressure: 0mmHg at 25°C 
  • Refractive Index: 1.586 
  • Boiling Point: 531.178 °C at 760 mmHg 
  • PKA: -0.77±0.10(Predicted) 
  • Flash Point: 275.047 °C 
  • PSA： 71.54000 
  • Density: 1.466 g/cm3 
  • LogP: 4.77760 

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine(Cas 799842-07-2) Usage

InChI:InChI=1/C16H19BrFN3O2S/c1-10(2)14-13(9-17)15(11-5-7-12(18)8-6-11)20-16(19-14)21(3)24(4,22)23/h5-8,10H,9H2,1-4H3

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799842-07-2 Process route

N-[5-chloromethyl-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide
925422-06-6

N-[5-chloromethyl-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
Conditions Yield
With hydrogen bromide; In water; at 80 ℃; for 15h;
94%
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
Conditions Yield
With phosphorus tribromide; In toluene; acetonitrile; at 10 - 20 ℃; for 1h; Inert atmosphere;
99%
With phosphorus tribromide; In dichloromethane; at 0 - 10 ℃; for 1h;
90.6%
With phosphorus tribromide; In dichloromethane; at 20 ℃; for 1h;
82%
With phosphorus tribromide; In toluene; acetonitrile; at 15 - 30 ℃; for 1h;
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; With hydrogen bromide; In water; toluene; at 30 - 110 ℃;
With sodium hydrogencarbonate; In water; toluene; at 25 ℃; pH=7 - 7.5;
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; With hydrogen bromide; In water; at 60 - 65 ℃; for 4h;
With potassium phosphate; In water; toluene; at 0 - 20 ℃; for 0.25h;
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; With tetrabutylammomium bromide; hydrogen bromide; In water; toluene; at 90 - 95 ℃; for 1.5h;
With sodium hydrogencarbonate; In water; toluene; Product distribution / selectivity;
With phosphorus tribromide; In dichloromethane; at 10 - 15 ℃; for 1h;
With phosphorus tribromide; In toluene; acetonitrile; at 20 ℃; for 1h;
Multi-step reaction with 2 steps
1: methanesulfonyl chloride; triethylamine / dichloromethane / 5 h / 0 - 25 °C
2: hydrogen bromide / water / 15 h / 80 °C
With hydrogen bromide; methanesulfonyl chloride; triethylamine; In dichloromethane; water;

799842-07-2 Upstream products

  • 147118-36-3
    147118-36-3

    N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

  • 953776-62-0
    953776-62-0

    N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide

  • 147118-30-7
    147118-30-7

    ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid

  • 925422-06-6
    925422-06-6

    N-[5-chloromethyl-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

799842-07-2 Downstream products

  • 956034-83-6
    956034-83-6

    C24 H24 F3 N5 O3 S2

  • 956034-87-0
    956034-87-0

    C24 H26 FN5 O3 S2

  • 956034-90-5
    956034-90-5

    N-((5-(1H-benzo[d]imidazol-2-ylthio)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methyimethanesulfonamide

  • 853066-73-6
    853066-73-6

    tributyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphonium bromide

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