(4R-CIS)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]- 1h-pyrrol-1-ylethyl]-2,2-dimethyl-1,3-dioxane-4-acetate (L1)
- CAS：125971-95-1
- purity：99%
Details
Quality Manufacturer Supply High Purity 99% (4R-CIS)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]- 1h-pyrrol-1-ylethyl]-2,2-dimethyl-1,3-dioxane-4-acetate (L1) 125971-95-1 with Reasonable Price
- Molecular Formula: C40H47FN2O5
- Molecular Weight: 654.822
- Melting Point: 144-148 °C
- Boiling Point: 678.035 °C at 760 mmHg
- PKA: 13.57±0.70(Predicted)
- Flash Point: 363.863 °C
- PSA： 78.79000
- Density: 1.15 g/cm3
- LogP: 9.44200
tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate(Cas 125971-95-1) Usage
InChI:InChI:1S/C40H47FN2O5/c1-26(2)36-34(27-14-10-8-11-15-27)35(38(45)42-30-16-12-9-13-17-30)37(28-18-20-29(41)21-19-28)43(36)23-22-31-24-32(47-40(6,7)46-31)25-33(44)48-39(3,4)5/h8-21,26,31-32H,22-25H2,1-7H3,(H,42,45)
125971-95-1 Relevant articles
AN IMPROVED AND COMMERCIALLY VIABLE PROCESS FOR PREPARATION OF PYRROLE DERIVATIVES WITH IMPROVED IMPURITY PROFILE & MINIMISATION OF UNIT OPERATIONS.
-
Page/Page column 68-69; 71, (2020/02/14)
The present invention relates to improve...
[18F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action
Antunes, Inês F.,Clemente, Gon?alo S.,D?mling, Alexander,Elsinga, Philip H.,Rickmeier, Jens,Ritter, Tobias,Zarganes-Tzitzikas, Tryfon
, (2020/04/24)
Background: Statins are lipid-lowering a...
Novel method for preparing atorvastatin key intermediate L1 through solvent-free method
-
Paragraph 0037-0086, (2019/11/12)
The invention discloses a novel method f...
Separating method for impurity A and impurity B and method for effectively reducing content of impurity A in atorvastatin calcium condensate
-
Paragraph 0071; 0072; 0073, (2019/01/16)
The invention discloses a separating met...
125971-95-1 Process route
-
-
1331869-19-2
C26 H22 FNO3
-
![tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate](/upload/2026/4/cf47299af58c460ebba2274e5ccec9f3_08ab8528-6177-4863-b451-3b1ef0bf1816.png)
-
125971-86-0,125995-13-3
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
![tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate](/upload/2026/4/27b72fe2246a4efaa1d61aaed742ca0c_55681638-6467-4c6e-b274-57b08ac753f1.png)
-
125971-95-1
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
| Conditions | Yield |
|---|---|
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene; Trimethylacetic acid;
In
cyclohexane;
at 80 - 84 ℃;
for 25h;
Concentration;
Reagent/catalyst;
Dean-Stark;
Reflux;
|
79%
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; hexane; toluene;
at 110 ℃;
for 30h;
Inert atmosphere;
|
-
-
125971-86-0,125995-13-3
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
![2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide](/upload/2026/4/4b7b246344974fa48eeb02a8a8a1a97f_21e8e987-4764-447f-86a6-efc0ff3eceb8.png)
-
125971-96-2,125971-58-6
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
-
-
125971-95-1
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
| Conditions | Yield |
|---|---|
|
With
Trimethylacetic acid;
In
toluene;
at 105 - 110 ℃;
for 1h;
Industrial scale;
|
96.5%
|
|
With
tetra(n-butyl)ammonium hydrogensulfate; diisopropylamine; Trimethylacetic acid;
at 78 - 85 ℃;
for 40h;
|
82.3%
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
Heating;
|
75%
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran;
for 40 - 72h;
Heating / reflux;
|
75.1%
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
for 48h;
Heating / reflux;
|
72.3%
|
|
With
tetra(n-butyl)ammonium hydrogensulfate; Trimethylacetic acid;
at 120 ℃;
for 5.5h;
Temperature;
Reagent/catalyst;
|
69.6%
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
Heating;
|
|
|
triethylamine; Trimethylacetic acid;
In
tetrahydrofuran; hexane;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
hydrogenchloride; triethylamine;
In
tetrahydrofuran; tert-butyl methyl ether;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
triethylamine; Trimethylacetic acid;
In
tetrahydrofuran; tert-butyl methyl ether;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
N-ethyl-N,N-diisopropylamine; Trimethylacetic acid;
In
toluene;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
sodium hydroxide; Trimethylacetic acid;
In
toluene;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
sodium hydroxide; Trimethylacetic acid;
In
tetrahydrofuran; tert-butyl methyl ether;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
zinc diacetate;
In
tetrahydrofuran; tert-butyl methyl ether;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
N-ethylmorpholine;; Trimethylacetic acid;
In
toluene;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
calcium hydroxide; Trimethylacetic acid;
In
tetrahydrofuran; tert-butyl methyl ether;
at 50 ℃;
Product distribution / selectivity;
Heating / reflux;
|
|
|
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide;
In
cyclohexane;
at 25 - 30 ℃;
for 0.25 - 0.333333h;
With
Trimethylacetic acid;
In
cyclohexane;
Heating / reflux;
|
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; hexane;
at 75 ℃;
for 96h;
Product distribution / selectivity;
|
|
|
With
Trimethylacetic acid;
In
cyclohexane;
at 20 ℃;
Heating / reflux;
|
|
|
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide;
Trimethylacetic acid;
In
tetrahydrofuran; cyclohexane;
at 25 - 85 ℃;
for 18h;
Heating / reflux;
With
ammonia;
In
tetrahydrofuran; cyclohexane; water;
at 20 - 35 ℃;
for 0.833333h;
pH=8.5 - 9.5;
|
|
|
Trimethylacetic acid;
In
2-methyl THF;
for 30 - 35h;
Heating / reflux;
|
|
|
With
Trimethylacetic acid;
In
cyclohexane; isopropyl alcohol;
|
|
|
With
Trimethylacetic acid;
In
cyclohexane;
at 20 - 78 ℃;
|
|
|
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide;
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
for 40h;
Heating / reflux;
With
sodium hydroxide;
In
tetrahydrofuran; n-heptane; water; toluene;
With
hydrogenchloride;
In
tetrahydrofuran; n-heptane; water; toluene;
|
|
|
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide;
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
for 40h;
Heating / reflux;
With
sodium hydroxide;
In
tetrahydrofuran; n-heptane; water; toluene;
With
hydrogenchloride;
In
tetrahydrofuran; n-heptane; water; toluene;
|
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
for 40h;
Heating / reflux;
|
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
for 40h;
Heating / reflux;
|
|
|
With
Trimethylacetic acid;
In
n-heptane;
at 100 ℃;
|
|
|
|
|
|
With
2,2-dimethylpropanoic anhydride;
In
2-methyltetrahydrofuran;
at 150 ℃;
for 4h;
Temperature;
Autoclave;
Inert atmosphere;
Green chemistry;
|
65 g
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; toluene;
Reflux;
|
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane;
for 60h;
Reflux;
|
|
|
With
Trimethylacetic acid;
In
tetrahydrofuran; hexane; toluene;
Reflux;
|
125971-95-1 Upstream products
-
125971-86-0
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
125971-96-2
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
-
124401-38-3
4-methyl-3-oxo-N-phenylpentanamide
-
100-52-7
benzaldehyde
125971-95-1 Downstream products
-
340266-37-7
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt
-
125995-03-1
atorvastatin lactone
-
134395-00-9
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
-
134523-02-7
atorvastatin potassium
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