(1-(2-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol

  • CAS：114798-26-4
  • purity：99%
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99% Purity Commercial production (1-(2-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol 114798-26-4 with Cheapest Price We supply high quality Losartan (CAS 114798-26-4), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Losartan ?

Losartan is pale yellow solid, while it's Molecular Formula is C22H23ClN6O. antihypertensive;antagonist of angiotensin type 1

What is the CAS number for Losartan ?

The CAS number of Losartan is 114798-26-4.

More information of Losartan 114798-26-4 are:

Synonyms

2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole;DUP 89;1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2-(2H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol;2-Butyl-4-chloro-1-[[2-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol;Losartan Base;

CAS?Number

114798-26-4

Molecular Formula

C22H23ClN6O

Molecular Weight

422.917

Density

1.35 g/cm3

Melting Point

183-184 °C

Boiling Point

682 °C at 760mmHg

Flash Point

366.3 °C

HS CODE

2942000000

PSA

92.51000

LogP

4.26680

Pka

5-6(at 25℃)

What is Losartan (114798-26-4) used for?

Losartan, also known as Cozaar, is a nonpeptide angiotensin II AT1-receptor antagonist. It is an orally active compound with high specificity for the AT1 receptor. Losartan undergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid, mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potent than the parent hydroxyl compound. Losartan is a biphenylyltetrazole with a 1,1'-biphenyl group attached at the 5-position and an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position.

InChI:InChI=1/C22H23ClN6O/c1-2-3-9-20-24-21(23)19(14-30)29(20)13-15-10-11-17(16-7-5-4-6-8-16)18(12-15)22-25-27-28-26-22/h4-8,10-12,30H,2-3,9,13-14H2,1H3,(H,25,26,27,28)

Articles related to Losartan:

Article

Source

Novel and efficient debenzylation of N-benzyltetrazole derivatives with the rosenmund catalyst

Seki, Masahiko

, p. 3249 - 3255 (2014)

Unusual detritylation of tritylated tetrazole in Sartan molecules

Srimurugan, Sankareswaran,Suresh, Paulsamy,Babu, Balaji,Hiriyanna, Salmara Ganeshbhat,Pati, Hari Narayan

, p. 383 - 384 (2008)

How to get the best price on Losartan?

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