Details
Quality products?make an important contribution to long-term revenue and profitability. Top Quality Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8 Hot Sell In Stock
1.What is the BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
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936630-57-8
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
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24424-99-5
di-tert -butyl dicarbonate
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![(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid](/upload/2026/4/531685ba97b44fb19569efa8d137a244_3f75279c-9a71-400f-9a8c-68de680c6670.png)
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486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
1,4-dioxane; water;
at 20 ℃;
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91%
|
|
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid;
With
lithium hydroxide;
In
1,4-dioxane; water;
at 0 - 30 ℃;
di-tert-butyl dicarbonate;
In
1,4-dioxane; water;
at 25 - 30 ℃;
|
91%
|
|
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 24h;
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91%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
|
85%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
In
tetrahydrofuran;
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60.6%
|
|
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
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14 g
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|
With
sodium hydrogencarbonate;
In
methanol;
at 0 - 20 ℃;
for 6h;
|
|
|
With
sodium carbonate;
In
tetrahydrofuran; water;
at 25 - 30 ℃;
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30 g
|
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In
water;
at 20 ℃;
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88.8 g
|
|
With
sodium hydroxide;
In
water;
at 25 - 30 ℃;
|
|
|
With
sodium hydroxide;
In
water;
at 25 - 30 ℃;
|
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1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
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486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
With
sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
water; acetonitrile;
at 38 ℃;
for 0.333333h;
Solvent;
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98%
|
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With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide;
In
dichloromethane;
at 0 ℃;
for 2h;
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90%
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(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate;
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide;
In
dichloromethane;
at 0 ℃;
for 2h;
With
hydrogenchloride;
In
dichloromethane; water;
pH=2 - 3;
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90%
|
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With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
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90%
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2.What is the CAS number for BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
The CAS number of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID is 486460-00-8.
More information of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8 are:
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CAS?Number |
486460-00-8 |
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Density |
1.292 g/cm3 |
|
Melting Point |
136-138℃ |
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Boiling Point |
443.1 °C at 760 mmHg |
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Flash Point |
221.8 °C |
|
Vapor Pressure |
1.25E-08mmHg at 25°C |
|
Refractive Index |
1.494 |
|
HS CODE |
2942000000 |
|
PSA |
75.63000 |
|
LogP |
3.40530 |
|
Pka |
4.30±0.10(Predicted) |
3.What are another words for BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
Synonyms?for?BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8:Benzenebutanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-,(bR)-;(3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoicacid;(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoicacid;(3R)-3-[N-(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoicacid;(R)-3-(((tert-Butoxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butyricacid;(R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid;
4.What is the molecular formula of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID?
The chemical formula of ?BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID is?C15H18F3NO4 which containing 15 Carbon atoms,18 Hydrogen atoms,3 Fluorine atoms,1 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of??BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID?is 333.307.
5.What is BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID (486460-00-8) used for?
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
InChI:InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/m1/s1
Relevant articles related to BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID:
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Article |
Source |
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Nickel-Catalyzed Asymmetric Hydrogenation for the Synthesis of a Key Intermediate of Sitagliptin |
Sudhakaran, Shana,Shinde, Prasad G.,Aratikatla, Eswar K.,Kaulage, Sandeep H.,Rana, Priksha,Parit, Ratan S.,Kavale, Dattatry S.,Senthilkumar, Beeran,Punji, Benudhar supporting information, (2021/12/09) |
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Preparation method of chiral 4 - aryl - β β-amino acid derivative |
- , (2021/11/14) |
6.Buy BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID with the best price .
FOND EVER CO.,LIMITED is a quality supplier of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8.
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