Buy reliable Quality (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5- trifluorophenyl)butan-1-one 486460-32-6 raw material with Honest Price

Quality products?make an important contribution to long-term revenue and profitability. Buy reliable Quality (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5- trifluorophenyl)butan-1-one 486460-32-6 raw material with Honest Price

1.What is the Sitagliptin ?

Sitagliptin is approved by the FDA as an adjunct to diet and exercise to improve glycaemic control in patients with T2DM, either as a monotherapy, or in combination with metformin or a peroxisome proliferatoractivated receptor-γ agonist (for example, thiazolidinediones) when the single agent does not provide adequate glycaemic control.

Labeled Sitagliptin , intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry.

: 1380521-88-9
(R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine

: 486460-32-6,823817-55-6
sitagliptin

Conditions

Conditions	Yield
With 30% w/w Pd(OH)2/C; hydrogen; In methanol; for 24h; under 3800.26 Torr;	96%
With 5%-palladium/activated carbon; hydrogen; acetic acid; In methanol; at 50 ℃; for 48h; under 19001.3 Torr;	95%

: 769195-20-2
(3R)-3-[[(1S)-1-carboxamidophenylmethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

: 486460-32-6,823817-55-6
sitagliptin

Conditions

Conditions	Yield
With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In methanol; water; at 50 ℃; for 14h; under 7500.75 Torr;	85%

2.What is the CAS number for Sitagliptin ?

The CAS number of Sitagliptin is 486460-32-6.

More information of Sitagliptin 486460-32-6 are:

CAS?Number	486460-32-6
Density	1.61 g/cm³
Melting Point	114.1-115.7 °C
Boiling Point	529.9 °C at 760 mmHg
Flash Point	274.3 °C
Vapor Pressure	0mmHg at 25°C
Refractive Index	1.59
PSA	77.04000
LogP	2.65470
Pka	7.20±0.10(Predicted)

3.What are another words for Sitagliptin ?

Synonyms?for?Sitagliptin 486460-32-6:1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-(9CI);(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine;(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-;

4.What is the molecular formula of Sitagliptin?

The chemical formula of ?Sitagliptin is?C16H15F6N5O which containing 16 Carbon atoms,15 Hydrogen atoms,6 Fluorine atoms,5 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??Sitagliptin?is 407.318.

5.What is Sitagliptin (486460-32-6) used for?

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

InChI:InChI=1/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m0/s1

Relevant articles related to Sitagliptin:

Article

Source

Identification of ammonium chloride as an effective promoter of the asymmetric hydrogenation of a β-enamine amide

Clausen, Andrew M.,Dziadul, Brianne,Cappuccio, Kristine L.,Kaba, Mahmoud,Starbuck, Cindy,Hsiao, Yi,Dowling, Thomas M.

, p. 723 - 726 (2006)

Preparation method of chiral 4 - aryl - β β-amino acid derivative

-

, (2021/11/14)

6.Buy Sitagliptin with the best price .

FOND EVER CO.,LIMITED is a quality supplier of Sitagliptin. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Sitagliptin 486460-32-6.

Sitagliptin Phosphate

Product classification

(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5- trifluorophenyl)butan-1-one

Details