Ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate(DG06

  • CAS：429659-01-8
  • purity：99%
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Factory sells Ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate(DG06 429659-01-8 with sufficient production capacity

  • Molecular Formula: C18H20N4O5
  • Molecular Weight: 372.381
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 86-88 °C 
  • Refractive Index: 1.631 
  • Boiling Point: 583.339 °C at 760 mmHg 
  • PKA: 2.62±0.10(Predicted) 
  • Flash Point: 306.592 °C 
  • PSA： 117.35000 
  • Density: 1.326 g/cm3 
  • LogP: 3.61780 

ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE(Cas 429659-01-8) Usage

InChI:InChI=1/C18H20N4O5/c1-3-27-17(23)9-11-21(16-6-4-5-10-20-16)18(24)13-7-8-14(19-2)15(12-13)22(25)26/h4-8,10,12,19H,3,9,11H2,1-2H3

429659-01-8 Relevant articles

Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of Ethyl 3-(3-Amino-4-(Methylamino)-N-(Pyridin-2-Yl) Benzamido)Propanoate

Liu,Peng,Yue,Li,Zhang

, p. 2009 - 2014 (2020/01/11)

A new heterocyclic compound ethyl 3-(3-a...

A novel benzimidazole pyridine salt compound and its synthetic method (by machine translation)

-

Paragraph 0058, (2019/10/02)

The present invention provides a benzimi...

METHOD FOR PREPARING DABIGATRAN ETEXILATE INTERMEDIATE, AND INTERMEDIATE COMPOUND

-

Paragraph 0064, (2017/08/01)

Disclosed are a method for preparing a d...

Multi-substituted 4-methyl ester derivative of amino benzonitrile trunk and its preparation and use

-

Paragraph 0096; 0111-0113, (2018/01/19)

The invention provides new ester derivat...

429659-01-8 Process route

3-[(4-chloro-3-nitrobenzoyl)pyridin-2-yl-amino]propionic acid ethyl ester
1620205-04-0

3-[(4-chloro-3-nitrobenzoyl)pyridin-2-yl-amino]propionic acid ethyl ester

methylamine
74-89-5

methylamine

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
Conditions Yield
In ethanol; N,N-dimethyl acetamide; at 70 ℃; for 0.5h; Solvent; Temperature;
99.39%
In ethanol; N,N-dimethyl acetamide; at 70 ℃; for 0.5h; Solvent; Temperature;
99.39%
In ethanol; at 40 ℃; for 2h; Autoclave;
84.6%
In ethanol; N,N-dimethyl-formamide; at 25 - 70 ℃; for 0.5h; Solvent;
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

Conditions
Conditions Yield
With triethylamine; In tetrahydrofuran; at 20 ℃;
4-methylamino-3-nitro-benzoic acid chloride; With triethylamine; In dichloromethane; at 0 - 10 ℃;
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate; In dichloromethane; at 0 - 30 ℃;
180 g
With triethylamine; In dichloromethane; at 20 ℃; for 12h;
With triethylamine; In dichloromethane; at 0 - 5 ℃; Inert atmosphere;

429659-01-8 Upstream products

  • 103041-38-9
    103041-38-9

    2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

  • 82357-48-0
    82357-48-0

    4-methylamino-3-nitro-benzoic acid chloride

  • 41263-74-5
    41263-74-5

    4-(methylamino)-3-nitrobenzoic acid

  • 96-99-1
    96-99-1

    4-chloro-3-nitrobenzoate

429659-01-8 Downstream products

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    N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alanine ethyl ester methanesulfonate

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    dabigatran etexilate fumarate

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