Details
Quality products?make an important contribution to long-term revenue and profitability. China cas 915095-86-2 factory wholesale (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone at affordable price
1.What is the (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone ?
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.
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281652-58-2
2-chloro-5-iodobenzoylchloride
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462-06-6
fluorobenzene
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915095-86-2
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
| Conditions | Yield |
|---|---|
|
With
aluminum (III) chloride;
In
dichloromethane;
at -5 ℃;
for 6h;
|
93.4%
|
|
2-chloro-5-iodobenzoylchloride; fluorobenzene;
With
aluminum (III) chloride;
at 0 - 75 ℃;
for 1.5h;
With
water;
at 0 - 25 ℃;
|
|
|
With
aluminum (III) chloride;
at 0 - 25 ℃;
for 1h;
regioselective reaction;
|
121 g
|
|
With
aluminum (III) chloride;
at 25 ℃;
Inert atmosphere;
|
105 g
|
|
With
aluminum (III) chloride;
In
dichloromethane;
at 20 ℃;
for 3h;
Cooling with ice;
|
42.1 g
|
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462-06-6
fluorobenzene
-
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19094-56-5
2-chloro-5-iodobenzoic acid
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915095-86-2
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
| Conditions | Yield |
|---|---|
|
With
oxalyl dichloride;
N,N-dimethyl-formamide;
at 25 - 30 ℃;
for 5h;
|
94%
|
|
fluorobenzene; 2-chloro-5-iodobenzoic acid;
With
oxalyl dichloride;
In
N,N-dimethyl-formamide;
at 25 - 30 ℃;
for 5h;
With
aluminum (III) chloride; water;
at 20 - 30 ℃;
for 6h;
|
94%
|
|
With
aluminum (III) chloride; oxalyl dichloride;
In
N,N-dimethyl-formamide;
at 25 - 45 ℃;
Industry scale;
|
94%
|
|
2-chloro-5-iodobenzoic acid;
With
oxalyl chloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
fluorobenzene;
With
aluminum (III) chloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
|
92%
|
|
2-chloro-5-iodobenzoic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 3h;
fluorobenzene;
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 5 ℃;
for 1h;
|
78.6%
|
|
2-chloro-5-iodobenzoic acid;
With
thionyl chloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 39 - 42 ℃;
fluorobenzene;
With
aluminum (III) chloride;
Reflux;
|
310 g
|
2.What is the CAS number for (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone ?
The CAS number of (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is 915095-86-2.
More information of (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 are:
|
CAS?Number |
915095-86-2 |
|
Density |
1.752 |
|
Boiling Point |
415℃ |
|
Flash Point |
205℃ |
|
HS CODE |
29142990 |
|
PSA |
17.07000 |
|
LogP |
4.31470 |
3.What are another words for (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone ?
Synonyms?for?(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2:Empagliflozin intermediate;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;
4.What is the molecular formula of (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone?
The chemical formula of ?(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is?C13H7ClFIO which containing 13 Carbon atoms,7 Hydrogen atoms,1 Chlorine atoms,1 Fluorine atoms,1 Iodine atoms and 1 Oxygen atoms,and the molecular weight of??(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone?is 360.554.
5.What is (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone (915095-86-2) used for?
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is an organic compound that serves as a key intermediate in the synthesis of Empagliflozin (E521510), a potent inhibitor of the SGLT-2 enzyme. (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is characterized by its unique structure, featuring a chloro and iodophenyl group connected to a fluorophenyl group through a methanone bridge. Its chemical properties make it a valuable reagent in pharmaceutical chemistry for the development of novel therapeutic agents.
Relevant articles related to (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone:
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Article |
Source |
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Dicyclic derivative of glucoside as well as preparation method and application of dicyclic derivative |
- Paragraph 0196; 0197; 0198, (2018/07/30) |
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Preparation method of SGLT2 inhibitor intermediate |
- Paragraph 0038-0039, (2017/08/30) |
6.Buy (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone with the best price .
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