(5R)-3-(4-Bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

  • CAS：444335-16-4
  • purity：99%
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Quality products?make an important contribution to long-term revenue and profitability. Manufacturer supply top purity (5R)-3-(4-Bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one 444335-16-4 with ISO standards

1.What is the (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE ?

Used in Pharmaceutical Industry:
(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE is used as a potential precursor in the development of new antibiotics due to its structural features and the inherent properties of the oxazolidinone class of antibiotics. The presence of the bromine and fluorine atoms, along with the hydroxymethyl group, may contribute to its potential as a novel antimicrobial agent, offering a new avenue for combating resistant bacterial strains.
Additionally, given the compound's unique stereochemistry and functional groups, it may also be utilized in the development of other pharmaceutical agents, where its specific structural attributes could be leveraged for targeted therapeutic effects or improved pharmacokinetic profiles. Further research and development would be necessary to explore these potential applications fully.

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester
510729-01-8

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

(R)-glycidyl butyrate
60456-26-0

(R)-glycidyl butyrate

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one
444335-16-4,1369530-77-7

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one

Conditions
Conditions Yield
With lithium tert-butoxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;
87%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃;
(R)-glycidyl butyrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; at 20 ℃; for 3h;
87%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With n-butyllithium; In tetrahydrofuran; hexane; tert-butyl alcohol; at 0 ℃; for 0.5h;
(R)-glycidyl butyrate; In tetrahydrofuran; hexane; tert-butyl alcohol; at 0 - 20 ℃;
86.4%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.33333h; Inert atmosphere;
(R)-glycidyl butyrate; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;
80%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
(R)-glycidyl butyrate; In tetrahydrofuran; hexane; at 20 ℃; for 24h;
65%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.25h;
(R)-glycidyl butyrate; In tetrahydrofuran; at 20 ℃; for 61h;
45.3%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.25h;
(R)-glycidyl butyrate; In tetrahydrofuran; at -78 - 20 ℃; for 61h;
45.3%
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With lithium tert-butoxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
(R)-glycidyl butyrate; In tetrahydrofuran; at 20 ℃; for 16h;
(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one
149524-42-5

(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one
444335-16-4,1369530-77-7

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one

Conditions
Conditions Yield
With silver trifluoroacetate; bromine chloride; In acetonitrile; at 20 ℃; for 24h;
92%
With bromine; In chloroform; at 20 ℃;

2.What is the CAS number for (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE ?

The CAS number of (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE is 444335-16-4.

More information of (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE 444335-16-4 are:

CAS?Number

444335-16-4

Density

1.701±0.06 g/cm3(Predicted)

Boiling Point

401.6±35.0 °C(Predicted)

Refractive Index

1.589

HS CODE

2934999090

PSA

49.77000

LogP

1.97070

Pka

14.05±0.10(Predicted)

3.What are another words for (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE ?

Synonyms?for?(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE 444335-16-4:(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one;

4.What is the molecular formula of (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE?

The chemical formula of ?(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE is?C10H9 Br F N O3 which containing 10 Carbon atoms,9 Hydrogen atoms,1 Bromine atoms,1 Fluorine atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE?is 290.089.

5.What is (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE (444335-16-4) used for?

(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE is a derivative of oxazolidinone, a class of antibiotics known for their effectiveness in treating bacterial infections. This specific compound features a hydroxymethyl group and a bromine-fluorine substituted phenyl ring, along with a unique (5R) stereochemistry that influences the positioning of its substituents on the oxazolidinone ring. The combination of these structural elements suggests potential biological activity and the possibility of influencing reactivity and pharmacological properties, making it a candidate for the development of new antibiotics or other pharmaceutical agents.

InChI:InChI=1/C10H9BrFNO3/c11-8-2-1-6(3-9(8)12)13-4-7(5-14)16-10(13)15/h1-3,7,14H,4-5H2/t7-/m1/s1

Relevant articles related to (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE:

Article

Source

OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS

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Page/Page column 37, (2017/05/19)

Oxazolidinone-quinolone hybrid antibiotics

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Page/Page column 28; 29, (2015/11/10)

6.Buy (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE with the best price .

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