3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-0xazolidi

  • CAS：856866-72-3
  • purity：99%
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Quality products?make an important contribution to long-term revenue and profitability. Factory Sells Best Quality 3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-0xazolidi 856866-72-3 with steady supply

1.What is the Torezolid ?

Tedizolid phosphate is an oxazolidinone compound used in the treatment of acute bacterial skin and skin structure infections caused by the following gram-positive bacteria-sensitive strains: Staphylococcus aureus (including Methicillin-resistant and methicillin-susceptible strains), pyogenic streptococci, Streptococcus lactis, Streptococcus angustifolia (including Angina, Streptococcus intermedius and Streptococcus constellation), and Enterococcus faecalis.

2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
1056039-83-8

2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one
444335-16-4,1369530-77-7

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
856866-72-3

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

Conditions
Conditions Yield
With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; Reagent/catalyst; Solvent; Temperature; Reflux; Inert atmosphere;
84%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; for 4h; Reagent/catalyst; Solvent; Inert atmosphere; Reflux;
78%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere; Large scale;
73%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; toluene; for 12h; Solvent; Reflux; Inert atmosphere;
63.7%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate;
2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one; With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; at 60 ℃; for 5h; Inert atmosphere; Large scale;
With L-Cysteine; triethylamine; at 60 ℃; for 16h; Inert atmosphere; Darkness; Large scale;
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 12h; Reflux;
80.2 g
(5R)-3-[3-fluoro-4-(tributylstannyl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

(5R)-3-[3-fluoro-4-(tributylstannyl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine
380380-64-3

5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
856866-72-3

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

Conditions
Conditions Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 4h; Temperature; Reagent/catalyst;
48%
With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; for 4h;
26%
With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 4h; Inert atmosphere;
26%
With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; at 120 ℃; for 4h;

2.What is the CAS number for Torezolid ?

The CAS number of Torezolid is 856866-72-3.

More information of Torezolid 856866-72-3 are:

CAS?Number

856866-72-3

Density

1.57

Melting Point

201 °C

Boiling Point

614.5±65.0 °C(Predicted)

HS CODE

29339900

PSA

106.26000

LogP

1.46070

Pka

14.05±0.10(Predicted)

3.What are another words for Torezolid ?

Synonyms?for?Torezolid 856866-72-3:Torezolid

4.What is the molecular formula of Torezolid?

The chemical formula of ?Torezolid is?C17H15FN6O3 which containing 17 Carbon atoms,15 Hydrogen atoms,1 Fluorine atoms,6 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Torezolid?is 370.343.

5.What is Torezolid (856866-72-3) used for?

Torezolid, also known as Torezolid phosphate, is a member of the class of pyridines that is pyridine which is substituted by a 2-methyl-2H-tetrazol-5-yl group at position 2 and by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl group at position 5. It is a synthetic antibiotic that belongs to the oxazolidinone class of antibiotics.
Used in Pharmaceutical Industry:
Torezolid is used as an antibiotic for the treatment of acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis. It works by inhibiting bacterial protein synthesis, thereby killing or stopping the growth of bacteria. Torezolid phosphate is used as a pro-drug, which is converted to the active form, Torezolid, in the body.

Relevant articles related to Torezolid:

Article

Source

Purification method of tedizolid phosphate

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Paragraph 0035, (2021/06/21)

Preparation method of tedizolid phosphate and intermediate thereof

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Paragraph 0076-0078, (2020/02/27)

6.Buy Torezolid with the best price .

FOND EVER CO.,LIMITED is a quality supplier of Torezolid. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Torezolid 856866-72-3.

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