Details
Cost-effective and customizable 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2 factory
- Molecular Formula: C11H8FNO
- Molecular Weight: 189.189
- Melting Point: 133 °C
- Boiling Point: 370.6±32.0 °C(Predicted)
- PKA: 14.77±0.50(Predicted)
- PSA： 32.86000
- Density: 1.270±0.06 g/cm3(Predicted)
- LogP: 2.63330
881674-56-2 Relevant articles
Preparation method of fumaric acid Vonoprazan intermediate
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Paragraph 0061-0085, (2021/07/28)
The invention relates to a preparation m...
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
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Paragraph 0079-0100, (2021/10/20)
The invention provides a preparation met...
Synthesis method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde
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Paragraph 0023; 0025; 0035-0036, (2021/01/20)
The invention discloses a synthetic meth...
Preparation method of vonoprazan fumarate intermediate
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Paragraph 0056-0066, (2021/06/21)
The invention provides a preparation met...
881674-56-2 Process route
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1240948-77-9
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
-
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881674-56-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
| Conditions | Yield |
|---|---|
|
With
hydrogen; acetic acid;
In
tetrahydrofuran; water;
at 20 - 30 ℃;
for 5h;
Inert atmosphere;
|
90.54%
|
|
With
hydrogen; acetic acid;
In
tetrahydrofuran; water;
at 15 - 25 ℃;
for 4h;
Reagent/catalyst;
Temperature;
|
84.4%
|
|
With
pyridine; hydrogen; acetic acid;
In
water;
at 30 ℃;
for 20h;
Temperature;
Reagent/catalyst;
Industrial scale;
|
84.9%
|
|
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile;
With
hydrogen; acetic acid;
Raney-nickel;
In
tetrahydrofuran; water;
at 15 - 25 ℃;
for 3h;
With
water; sodium hydroxide;
In
tetrahydrofuran; ethyl acetate;
at 10 - 35 ℃;
pH=7 - 8;
With
hydrogenchloride; water;
In
tetrahydrofuran; ethyl acetate;
at 15 - 25 ℃;
pH=3 - 3.5;
|
78%
|
|
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile;
With
hydrogen; acetic acid;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
With
water; sodium hydroxide;
at 20 ℃;
pH=7 - 8;
|
76.9%
|
|
With
formic acid; water; hydrogen;
In
tetrahydrofuran;
for 2.5h;
under 750.075 Torr;
|
51.5%
|
|
With
hydrogen; acetic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 2h;
|
42%
|
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881674-58-4
(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol
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881674-56-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
| Conditions | Yield |
|---|---|
|
With
sodium bromate; sulfuric acid; bromine; sodium bromide;
In
dichloromethane; water; butan-1-ol;
at 0 - 5 ℃;
for 3.5h;
Solvent;
|
95.1%
|
|
With
[bis(acetoxy)iodo]benzene;
In
dichloromethane;
at 20 ℃;
for 12h;
|
92%
|
|
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
|
60%
|
|
With
4-methylmorpholine N-oxide;
tetrapropylammonium perruthennate;
In
acetonitrile;
at 20 ℃;
for 1.5h;
|
|
|
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
Molecular sieve;
|
881674-56-2 Upstream products
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881674-58-4
(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol
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114615-82-6
tetrapropylammonium perruthennate
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881674-06-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester
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1240948-72-4
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
881674-56-2 Downstream products
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881677-08-3
4-{[2-(2-fluorophenyl)-4-formyl-1H-pyrrol-1-yl]sulfonyl}benzonitrile
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881677-11-8
5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde
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881677-02-7
5-(2-fluorophenyl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde
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881681-30-7
1-[5-(2-fluorophenyl)-1-({3-[(trifluoromethyl)sulfonyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine hydrochloride
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