(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid

  • CAS：1012341-48-8
  • purity：99%
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Details

Reliable Quality (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid 1012341-48-8 Hot Sale with Chinese Manufacturer

  • Molecular Formula:C23H27NO4
  • Molecular Weight:381.472
  • Vapor Pressure:8.4-839.931Pa at 20℃ 
  • Boiling Point:595.6±50.0 °C(Predicted) 
  • PKA:4.67±0.19(Predicted) 
  • PSA：75.63000 
  • Density:1.132±0.06 g/cm3(Predicted) 
  • LogP:5.21120 

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1012341-48-8 Process route

ethyl 5-(4-<1,1'-biphenyl>yl)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-methyl-2-pentenoate
149709-59-1

ethyl 5-(4-<1,1'-biphenyl>yl)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-methyl-2-pentenoate

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
1012341-48-8

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

Conditions
Conditions Yield
With ethanol; lithium hydroxide; at 35 ℃; for 1h;
70%
With lithium hydroxide; ethanol;
With lithium hydroxide; at 80 ℃; for 1h;
With lithium hydroxide; In ethanol; water; at 80 ℃; for 1h;
55.4 g
ethyl 5-(4-<1,1'-biphenyl>yl)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-methyl-2-pentenoate; With lithium hydroxide; In ethanol; water; Reflux;
With acetic acid; In ethanol; water; for 0.25h; Reflux;
23.3 g
(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylenepentanoic acid
1174130-80-3

(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylenepentanoic acid

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
1012341-48-8

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

Conditions
Conditions Yield
With sodium hydrogencarbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium(0); In xylene; Reflux;
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;

1012341-48-8 Upstream products

  • 149709-59-1
    149709-59-1

    ethyl 5-(4-<1,1'-biphenyl>yl)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-methyl-2-pentenoate

  • 1174130-80-3
    1174130-80-3

    (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylenepentanoic acid

  • 1426129-50-1
    1426129-50-1

    N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester

  • 1213855-60-7
    1213855-60-7

    methyl (R)-3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

1012341-48-8 Downstream products

  • 1012341-50-2
    1012341-50-2

    (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

  • 1012341-54-6
    1012341-54-6

    (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

  • 1038924-71-8
    1038924-71-8

    (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride

  • 149690-12-0
    149690-12-0

    (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

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