Details
Purity 99% Min Sacubitril 149709-62-6 Spot Supply with Safe Transportation
- Molecular Formula:C24H29NO5
- Molecular Weight:411.498
- Boiling Point:656.9±55.0 °C(Predicted)
- PKA:4.72±0.10(Predicted)
- PSA：92.70000
- Density:1.151±0.06 g/cm3(Predicted)
- LogP:4.22590
149709-62-6 Relevant articles
Preparation method of sacubitril valsartan sodium
-
Page/Page column 11-14, (2021/03/31)
The invention provides a preparation met...
Preparation method of
-
, (2021/09/15)
The preparation method comprises the fol...
AMMONIUM CARBOXYLATE COMPOUND, CRYSTALLINE FORM, AMORPHOUS FORM AND PREPARATION METHOD THEREOF
-
Paragraph 170-171, (2020/03/01)
The present disclosure belongs to the fi...
Optimization and process improvement for LCZ696 by employing quality by design (QbD) principles
Chen, Zhijun,Wang, Hailong,Wu, Shuming,Wang, Jian,Zhang, Chenxia,Yang, Hua,Wang, Zhongqing
supporting information, (2020/09/10)
Efforts toward optimization and improvem...
149709-62-6 Process route
-
-
108-30-5
succinic acid anhydride
-
![(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride](/upload/2026/4/9714302abda94775a8617c5d71705cce_cd023d7d-019f-4a71-948c-f60b2a2d0310.png)
-
149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
-
-
149709-62-6,149709-63-7,766480-48-2
α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.5h;
|
88.3% |
|
With
triethylamine;
In
Isopropyl acetate;
at -5 - 30 ℃;
for 2h;
|
81.3% |
|
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
succinic acid anhydride;
In
dichloromethane;
at 0 ℃;
for 4h;
|
98.5 %Chromat. |
|
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
|
165 g |
|
With
triethylamine;
In
Isopropyl acetate;
at 0 - 20 ℃;
for 2h;
|
|
|
With
triethylamine;
In
Isopropyl acetate;
at 20 ℃;
|
|
|
With
thionyl chloride;
for 8h;
|
98 % ee |
|
With
triethylamine;
In
ethyl acetate; toluene;
at 0 - 5 ℃;
for 4.33333h;
Reagent/catalyst;
Solvent;
Temperature;
|
|
|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 10 - 20 ℃;
|
36 g |
|
With
triethylamine;
In
dichloromethane;
at 25 - 30 ℃;
for 3h;
|
|
|
With
triethylamine;
In
water; ethyl acetate;
at 20 - 30 ℃;
for 2.5h;
|
|
|
With
pyridine;
at 60 - 70 ℃;
|
52.4 g |
|
With
N-ethyl-N,N-diisopropylamine;
In
Isopropyl acetate;
at 25 ℃;
for 4h;
Temperature;
Solvent;
|
|
|
With
N-ethyl-N,N-diisopropylamine;
In
Isopropyl acetate;
at 0 - 10 ℃;
for 6h;
|
-
-
108-30-5
succinic acid anhydride
-
-
752174-62-2,753421-85-1
(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester
-
-
149709-62-6,149709-63-7,766480-48-2
α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate
| Conditions | Yield |
|---|---|
|
With
pyridine;
In
dichloromethane;
at 40 - 45 ℃;
for 10h;
|
77.9% |
|
succinic acid anhydride; (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester;
In
Isopropyl acetate;
at 20 ℃;
for 0.5h;
With
triethylamine;
In
Isopropyl acetate;
at -10 - 10 ℃;
|
|
|
With
pyridine;
In
dichloromethane;
|
|
|
With
triethylamine;
In
dichloromethane;
at 40 ℃;
for 1h;
Inert atmosphere;
Industrial scale;
|
13.9 g |
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene;
at 5 - 10 ℃;
for 1h;
|
20 g |
149709-62-6 Upstream products
-
149709-64-8
α-ethyl (αR,γS)-γ-<<3-(1,1-dimethylethoxy)-1-oxopropyl>amino>-α-methyl<1,1'-biphenyl>-4-pentanoate
-
128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
-
76757-90-9
N-(tert-butoxycarbonyl)-D-tyrosine methyl ester
-
753421-85-1
ethyl (γS)-γ-amino-α-methyl<1,1'-biphenyl>-4-pentanoate
149709-62-6 Downstream products
-
149690-05-1
α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt
Related Products
-
-
-
5-Bromoacetyl-2-bensyloxybenzoic acid methyl esterCAS：27475-14-5