Tert-butyl [(1R,2S,5S)-2-([(5-chloropyridin-2-yl)amino](oxo)acetyl}amino)-5-(dimethylaminocarbonyl) cycohexyl]carbamate

  • CAS：480452-36-6
  • purity：99%
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Quality products?make an important contribution to long-term revenue and profitability. Factory supply Tert-butyl [(1R,2S,5S)-2-([(5-chloropyridin-2-yl)amino](oxo)acetyl}amino)-5-(dimethylaminocarbonyl) cycohexyl]carbamate 480452-36-6 with sufficient stock and high standard

1.What is the EthanediaMide iMpurity D ?

(1R, 2S, 5S)-tert-Buty Edoxaban is an impurity of Edoxaban (E555520). Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.

(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide
929693-30-1

(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester
480452-36-6

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2.1: sodium azide; N-dodecylpyridinium chloride / toluene; water / 47 h / 60 - 63 °C / Dean-Stark
3.1: ammonium formate / palladium-carbon / methanol / 1 h / 40 °C
3.2: 17 h / 20 °C
4.1: triethylamine / acetonitrile / 6 h / 60 °C
With sodium azide; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; 4-methyl-2-pentanone (MIBK); water; toluene; acetonitrile;
Multi-step reaction with 5 steps
1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2: sodium azide; N-dodecylpyridinium chloride / ethyl acetate; N,N-dimethylacetamide (DMAC) / 72 h / 20 - 60 °C
3: ammonium formate / palladium-carbon / acetonitrile; methanol / 1 h / 40 °C
4: acetonitrile; water / 17 h / 20 °C
5: triethylamine / acetonitrile / 6 h / 60 °C
With sodium azide; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; N,N-dimethylacetamide (DMAC); 4-methyl-2-pentanone (MIBK); water; ethyl acetate; acetonitrile;
Multi-step reaction with 5 steps
1: triethylamine / 1 h / 15 - 30 °C
2: dodecylpyridinium chloride; sodium azide / toluene / 72 h / 60 °C
3: palladium-carbon; ammonium formate / methanol / 1 h / 40 °C
4: acetonitrile; water / 17 h / 20 °C
5: triethylamine / acetonitrile / 22 h / 20 - 60 °C
With sodium azide; palladium-carbon; ammonium formate; dodecylpyridinium chloride; triethylamine; In methanol; water; toluene; acetonitrile;
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide
929693-30-1

(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester
480452-36-6

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester

C<sub>23</sub>H<sub>25</sub>Cl<sub>2</sub>N<sub>7</sub>O<sub>5</sub>

C23 H25 Cl2 N7 O5

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2: sodium azide; N-dodecylpyridinium chloride / ethyl acetate; N,N-dimethylacetamide (DMAC) / 72 h / 20 - 60 °C
3: ammonium formate / palladium-carbon / acetonitrile; methanol / 1 h / 40 °C
4: acetonitrile; water / 17 h / 20 °C
5: triethylamine / acetonitrile / 7 h / 60 - 75 °C
With sodium azide; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; N,N-dimethylacetamide (DMAC); 4-methyl-2-pentanone (MIBK); water; ethyl acetate; acetonitrile;

2.What is the CAS number for EthanediaMide iMpurity D ?

The CAS number of EthanediaMide iMpurity D is 480452-36-6.

More information of EthanediaMide iMpurity D 480452-36-6 are:

CAS?Number

480452-36-6

Density

1.29±0.1 g/cm3(Predicted)

PSA

129.73000

LogP

2.79470

Pka

9.46±0.70(Predicted)

3.What are another words for EthanediaMide iMpurity D ?

Synonyms?for?EthanediaMide iMpurity D 480452-36-6:EthanediaMide iMpurity D;tert-Butyl(1R,2S,5S)-2-({2-[(5-chloropyridin-2-yl)aMino]-2-oxoacetyl}aMino)-5-[(diMethylaMino)carbonyl]cyclohexyl-carbaMate;N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-2-[(tert-Butoxycarbonyl)Amino ]-4-[(dimethylamino)carbonyl]-cyclohexyl) oxalamide

4.What is the molecular formula of EthanediaMide iMpurity D?

The chemical formula of ?EthanediaMide iMpurity D is?C21H30ClN5O5 which containing 21 Carbon atoms,30 Hydrogen atoms,1 Chlorine atoms,5 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??EthanediaMide iMpurity D?is 467.953.

5.What is EthanediaMide iMpurity D (480452-36-6) used for?

EthanediaMide iMpurity D, also known as (1R, 2S, 5S)-tert-Buty Edoxaban, is an impurity found in Edoxaban (E555520). Edoxaban is an anticoagulant drug that acts as a direct factor Xa inhibitor, playing a crucial role in the prevention and treatment of various blood clot-related conditions.

Relevant articles related to EthanediaMide iMpurity D:

Article

Source

PROCESS FOR PREPARATION OF EDOXABAN

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Page/Page column 12; 20-22, (2021/01/23)

Improved preparation method of edoxaban intermediate

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Paragraph 0023-0064, (2020/10/21)

6.Buy EthanediaMide iMpurity D with the best price .

FOND EVER CO.,LIMITED is a quality supplier of EthanediaMide iMpurity D. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on EthanediaMide iMpurity D 480452-36-6.

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