2,4-Dichloro-5-fluoropyrimidine

  • CAS：2927-71-1
  • purity：99%
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Excellent chemical plant bulk supply 2,4-Dichloro-5-fluoropyrimidine 2927-71-1 We provide high quality 2,4-Dichloro-5-fluoropyrimidine (CAS 2927-71-1), at a very affordable prices to our customers.

1.What is the 2,4-Dichloro-5-fluoropyrimidine ?

2,4-Dichloro-5-fluoropyrimidine is a yellow to orange crystalline solid that serves as a versatile chemical intermediate in the synthesis of various biologically active compounds. It is characterized by the presence of two chlorine atoms at the 2nd and 4th positions and a fluorine atom at the 5th position on the pyrimidine ring.

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize: 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors. A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors. 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors. 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA. 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst. 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

2.What is the CAS number for 2,4-Dichloro-5-fluoropyrimidine ?

The CAS number of 2,4-Dichloro-5-fluoropyrimidine is 2927-71-1.

More information of 2,4-Dichloro-5-fluoropyrimidine 2927-71-1 are:

CAS?Number

2927-71-1

Density

1.605 g/cm3

Melting Point

37-41 °C(lit.)

Boiling Point

222.8 °C at 760 mmHg

Flash Point

88.6 °C

Vapor Pressure

0.148mmHg at 25°C

Refractive Index

1.531

HS CODE

29335990

PSA

25.78000

LogP

1.92250

Pka

-3.96±0.29(Predicted)

3.What is the molecular formula of 2,4-Dichloro-5-fluoropyrimidine ?

The chemical formula of?2,4-Dichloro-5-fluoropyrimidine is C4HCl2FN2 which containing 4 Carbon atoms,1 Hydrogen atoms,2 Chlorine atoms,1 Fluorine atoms and 2 Nitrogen atoms,and the molecular weight, and the molecular weight of 2,4-Dichloro-5-fluoropyrimidine is 166.97

4.What is 2,4-Dichloro-5-fluoropyrimidine(2927-71-1)used for?

2,4-Dichloro-5-fluoropyrimidine is a yellow to orange crystalline solid that serves as a versatile chemical intermediate in the synthesis of various biologically active compounds. It is characterized by the presence of two chlorine atoms at the 2nd and 4th positions and a fluorine atom at the 5th position on the pyrimidine ring.

InChI:InChI=1/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

Relevant articles related to 2,4-Dichloro-5-fluoropyrimidine:

Article

Source

Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis

Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua

supporting information, p. 146 - 153 (2020/03/10)

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