6-(Phthalimidomethyl)-6,11-dihydro-5H-dibenz-[b,e]azepine(PMDAP)

  • CAS：143878-20-0
  • purity：99%
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Details

Top quality factory supply 143878-20-0 6-(Phthalimidomethyl)-6,11-dihydro-5H-dibenz-[b,e]azepine(PMDAP) at low price

  • Molecular Formula:C23H18N2O2
  • Molecular Weight:354.408
  • Appearance/Colour:Off-white solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.662 
  • Boiling Point:557.301 °C at 760 mmHg 
  • PKA:3.94±0.40(Predicted) 
  • Flash Point:290.845 °C 
  • PSA：49.41000 
  • Density:1.284 g/cm3 
  • LogP:4.11610 

6-(Phthalimidomethyl)-6,11-dihydro-5H-dibenz[b,e]azepine(Cas 143878-20-0) Usage

InChI:InChI=1/C23H18N2O2/c26-22-18-10-4-5-11-19(18)23(27)25(22)14-21-17-9-3-1-7-15(17)13-16-8-2-6-12-20(16)24-21/h1-12,21,24H,13-14H2

143878-20-0 Relevant articles

The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

Roszkowski, Piotr,Maurin,Czarnocki, Zbigniew

, p. 1509 - 1513 (2015)

A simple enantioselective synthetic proc...

143878-20-0 Process route

N-<(11H-dibenz<b,e>azepin-6-yl)methyl>phthalimide
74860-00-7

N-<(11H-dibenzazepin-6-yl)methyl>phthalimide

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione
143878-20-0

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione

Conditions
Conditions Yield
With formic acid; palladium 10% on activated carbon; In N,N-dimethyl-formamide; at 70 ℃; for 3h;
95%
2-benzylaniline
28059-64-5

2-benzylaniline

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione
143878-20-0

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: triethylamine / chloroform / 1 h / 5 - 24 °C
2: trichlorophosphate / acetonitrile / 3 h / Reflux
3: formic acid; palladium 10% on activated carbon / N,N-dimethyl-formamide / 3 h / 70 °C
With formic acid; palladium 10% on activated carbon; triethylamine; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; acetonitrile;

143878-20-0 Upstream products

  • 28059-64-5
    28059-64-5

    2-benzylaniline

  • 6780-38-7
    6780-38-7

    N-phthaloylglycine chloride

  • 74860-00-7
    74860-00-7

    N-<(11H-dibenzazepin-6-yl)methyl>phthalimide

143878-20-0 Downstream products

  • 71936-92-0
    71936-92-0

    1,2,3,4,10,14b-hexahydrodibenzo[c,f]-pyrazino[1,2-a]azepine

  • 24219-97-4
    24219-97-4

    mianserin

  • 41218-84-2
    41218-84-2

    6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

  • 80012-43-7
    80012-43-7

    epinastine

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