3-(4-Phenoxy-phenyl)-1-piperidin-3-y-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

  • CAS：1022150-12-4
  • purity：99%
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Details

Top Quality Chinese Manufacturer supply 1022150-12-4 3-(4-Phenoxy-phenyl)-1-piperidin-3-y-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

  • Molecular Formula:C22H22N6O
  • Molecular Weight:386.456
  • Boiling Point:626.3±55.0 °C(Predicted) 
  • PKA:9.00±0.10(Predicted) 
  • PSA：90.88000 
  • Density:1.39±0.1 g/cm3(Predicted) 
  • LogP:4.70230 

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine(Cas 1022150-12-4) Usage

InChI:InChI=1S/C22H22N6O/c23-21-19-20(15-8-10-18(11-9-15)29-17-6-2-1-3-7-17)27-28(22(19)26-14-25-21)16-5-4-12-24-13-16/h1-3,6-11,14,16,24H,4-5,12-13H2,(H2,23,25,26)

1022150-12-4 Relevant articles

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The present invention provides a prepara...

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The invention relates to a preparation m...

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1022150-12-4 Process route

(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

Conditions
Conditions Yield
With hydrogen; In methanol; water; at 50 ℃; for 2h; under 1034.32 Torr; Acidic conditions;
67.4%
With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; In methanol; at 40 - 50 ℃;
With palladium 10% on activated carbon; hydrogen; In methanol;
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

Conditions
Conditions Yield
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; Temperature; Inert atmosphere; Large scale;
85%
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 30 ℃; for 25h; Concentration; Temperature;
80.45%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;
With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 5h;
69%
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
52%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 5.5h;
With hydrogenchloride; at 15 ℃; for 2.5h;
45%
Multi-step reaction with 2 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 50 °C
1.2: 20 h / 50 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 50 °C
With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; water;

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