Details
Manufacturer supply high quality N-Boc-3-hydroxypiperidine 85275-45-2 with GMP standards
- Molecular Formula: C10H19NO3
- Molecular Weight: 201.266
- Melting Point: 65-67 °C
- Boiling Point: 292.3 °C at 760 mmHg
- PKA: 14.74±0.20(Predicted)
- Flash Point: 130.6 °C
- PSA： 49.77000
- Density: 1.107 g/cm3
- LogP: 1.31610
85275-45-2 Relevant articles
Sustainable Route Toward N-Boc Amines: AuCl3/CuI-Catalyzed N-tert-butyloxycarbonylation of Amines at Room Temperature
Cao, Yanwei,Huang, Yang,He, Lin
, (2021/12/22)
N-tert-butoxycarbonyl (N-Boc) amines are...
Multi-chiral nitrogen-substituted piperidinol derivative and preparation method thereof
-
Paragraph 0017-0018, (2021/10/11)
The invention belongs to the technical f...
Preparation method of (S)-N-BOC-3-hydroxypiperidine
-
Paragraph 0060; 0067-0069; 0074; 0075; 0080, (2020/02/17)
The invention provides a preparation met...
Preparation method of N-tert-butyloxycarbonyl-3-piperidone and derivative thereof
-
Paragraph 0065-0066; 0068-0070, (2020/07/21)
The invention discloses a preparation me...
85275-45-2 Process route
-
-
34619-03-9
tert-butyldicarbonate
-
-
64051-79-2,198976-43-1
piperidin-3-ol hydrochloride
-
-
85275-45-2
N-tert-butoxycarbonyl-3-piperidinol
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![3-(3,4-dichlorophenyl)-3-hydroxy piperidine-1-carboxylic acid {4-[(2,2-dimethyl-propionylamino)-methyl]-phenyl}-amide](/upload/2026/4/0e81c0350d1046558c906b2ad7bedf5b_8f0cd9b6-4109-47d9-9e93-9b9466a8bdee.png)
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3-(3,4-dichlorophenyl)-3-hydroxy piperidine-1-carboxylic acid {4-[(2,2-dimethyl-propionylamino)-methyl]-phenyl}-amide
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
1,4-dioxane; hexane; ethyl acetate;
|
-
-
6859-99-0
3-hydroxypiperazine
-
-
24424-99-5
di-tert -butyl dicarbonate
-
-
85275-45-2
N-tert-butoxycarbonyl-3-piperidinol
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
|
100%
|
|
With
triethylamine;
In
methanol;
at 20 ℃;
for 15h;
|
99%
|
|
With
triethylamine;
In
methanol;
at 20 ℃;
for 15h;
|
99%
|
|
With
N-ethyl-N,N-diisopropylamine;
In
1,3-dioxane; water;
at 0 - 20 ℃;
for 5h;
|
98%
|
|
With
sodium hydrogencarbonate;
In
ethanol; water;
at 20 ℃;
for 4.5h;
|
97%
|
|
With
sodium hydrogencarbonate;
at 20 ℃;
for 4h;
Reagent/catalyst;
|
96.47%
|
|
With
triethylamine;
In
dichloromethane;
for 1h;
|
95%
|
|
In
chloroform;
at 100 ℃;
for 1.5h;
|
94%
|
|
With
sodium hydrogencarbonate;
for 48h;
Ambient temperature;
|
92%
|
|
In
water;
at 10 - 25 ℃;
|
90.6%
|
|
With
triethylamine;
In
ethanol;
at 0 - 20 ℃;
for 1h;
|
84%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
|
83.6%
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
|
78%
|
|
In
water (50 ml)-acetonitrile; water;
|
70%
|
|
|
|
|
In
dichloromethane;
|
|
|
In
dichloromethane;
at 20 ℃;
for 1h;
|
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
|
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
|
|
|
With
triethylamine;
In
ethanol;
at 10 - 20 ℃;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
|
|
|
In
sodium carbonate;
|
|
|
With
sodium hydrogencarbonate;
In
water;
at 20 ℃;
|
|
|
In
chloroform;
at 20 ℃;
|
|
|
With
triethylamine;
In
tetrahydrofuran;
at 0 ℃;
|
|
|
With
potassium carbonate;
In
water; ethyl acetate;
at 20 ℃;
for 16h;
|
|
|
With
triethylamine;
In
dichloromethane;
|
|
|
With
triethylamine;
In
dichloromethane;
for 3h;
|
|
|
With
triethylamine;
In
dichloromethane;
|
|
|
With
sodium carbonate;
In
methanol; water;
at 9 - 20 ℃;
|
675 g
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 2h;
pH=11;
|
|
|
With
sodium hydrogencarbonate;
In
water;
at 20 ℃;
for 20h;
Reagent/catalyst;
Time;
|
85275-45-2 Upstream products
-
6859-99-0
3-hydroxypiperazine
-
24424-99-5
di-tert -butyl dicarbonate
-
64051-79-2
piperidin-3-ol hydrochloride
-
34619-03-9
tert-butyldicarbonate
85275-45-2 Downstream products
-
98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
-
167143-55-7
1-t-butoxycarbonyl-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}piperidine
-
143900-44-1
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
-
143900-43-0
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
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